Molecular Cell
July 17 2025
YTHDC1 lactylation regulates its phase separation to enhance target mRNA stability and promote RCC progression
Chenyun Dai 1,2,3,4, Yuangui Tang 1,4, Huihui Yang 1, Junfang Zheng 1,5
1 Beijing Key Laboratory of Cancer Invasion and Metastasis Research, Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Capital Medical University, Beijing 100069, China
2 Tongji Hospital, School of Medicine, Tongji University, Shanghai 200065, China
3 State Key Laboratory of Neurology and Oncology Drug Development, Nanjing 210018, China
4 These authors contributed equally
5 Lead contact
10.1016/j.molcel.2025.06.017
A peacock unfurls its tail, symbolizing YTHDC1 undergoing phase separation upon lysine lactylation. The jewel on its neck marks the Kla-modified K82 site, while the eye-like patterns on its feathers represent nuclear condensates that safeguard oncogenic transcripts. Against a backdrop of swirling Tai Chi symbolism, the study captures the delicate equilibrium between RNA degradation and stabilization.
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