Cell
May 29 2025
Long-term histone lactylation connects metabolic and epigenetic rewiring in innate immune memory
Athanasios Ziogas1,2,15 , Boris Novakovic3 , Lorenzo Ventriglia1,4 , Noriko Galang1,2, Kim A. Tran5, Wenchao Li6,7, Vasiliki Matzaraki1, Nienke van Unen6,7, Titus Schlüter1, Anaísa V. Ferreira1, Simone J.C.F.M. Moorlag1, Valerie A.C.M. Koeken1,8, Mthabisi Moyo1,2,9, Xiaolin Li1,2,9, Marijke P.A. Baltissen10, Joost H.A. Martens10, Yang Li6,7,11,12, Maziar Divangahi5, Leo A.B. Joosten1,13, Musa M. Mhlanga1,2,9, Mihai G. Netea1,14
1 Department of Internal Medicine and Radboud Center for Infectious Diseases, Radboud University Medical Center, Nijmegen, the Netherlands
2 Department of Cell Biology, Faculty of Science, Radboud Institute for Molecular Life Sciences, Radboud University Nijmegen, Nijmegen, the Netherlands
3 Murdoch Children’s Research Institute and Department of Paediatrics, University of Melbourne, Royal Children’s Hospital, Parkville, Australia
4 Hepatogastroenterology Division, Department of Precision Medicine, University of Campania “Luigi Vanvitelli”, Naples, Italy
5 Department of Medicine, Department of Pathology, Department of Microbiology & Immunology, Research Institute of the McGill University Health Centre, McGill International TB Centre, Meakins-Christie Laboratories, McGill University, Montreal, QC, Canada
6 Department of Computational Biology of Individualised Medicine, Centre for Individualised Infection Medicine (CiiM), a Joint Venture Between the Hannover Medical School (MHH) and the Helmholtz Centre for Infection Research (HZI), Hannover, Germany
7 TWINCORE, Centre for Experimental and Clinical Infection Research, a Joint Venture Between the Hannover Medical School (MHH) and the Helmholtz Centre for Infection Research (HZI), Hannover, Germany
8 Research Centre Innovations in Care, Rotterdam University of Applied Sciences, Rotterdam, the Netherlands
9 Department of Human Genetics, Radboud University Medical Center, Nijmegen, the Netherlands
10 Department of Molecular Biology, Faculty of Science, Radboud University Nijmegen, Nijmegen, the Netherlands
11 Cluster of Excellence RESIST (EXC 2155), Hanover Medical School, Hannover, Germany
12 Lower Saxony center for artificial intelligence and causal methods in medicine (CAIMed), Hannover, Germany
13 Department of Medical Genetics, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania
14 Department for Immunology and Metabolism, Life and Medical Sciences Institute (LIMES), University of Bonn, Bonn, Germany
15 Lead contact
10.1016/j.cell.2025.03.048
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