Lab on a Chip
26 May 2020
Ultrasensitive optofluidic enzyme-linked immunosorbent assay by on-chip integrated polymer whispering-gallery-mode microlaser sensors
Xia Ouyang,a Tong Liu,a Yangxi Zhang,a Jijun He,ab Zijian He,a A. Ping Zhang*a and Hwa-Yaw Tama
a Photonics Research Centre, Department of Electrical Engineering, The Hong Kong Polytechnic University, Hong Kong, SAR, China
b Institute of Physics, École Polytechnique Fédérale de Lausanne (EPFL), CH-1015 Lausanne, Switzerland
10.1039/D0LC00240B
Optical whispering-gallery-mode (WGM) microcavities offer great promise in ultrasensitive biosensors because of their unique ability to enable resonant recirculation of light to achieve strong light–matter interactions in microscale volumes. However, it remains a challenge to develop cost-effective, high-performance WGM microcavity-based biosensing devices for practical disease diagnosis applications. In this paper, we present an optofluidic chip that is integrated with directly-printed, high-quality-factor (Q) polymer WGM microlaser sensors for ultrasensitive enzyme-linked immunosorbent assay (ELISA).
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