Analytical Chemistry Journal Cover Design Service (RCA)

Analytical Chemistry
September 19 2025
An RCA-CRISPR-Enhanced SERS Platform for Ultrasensitive and Single-Nucleotide-Resolved Detection of Exosomal miRNA-21 in Early Lung Cancer
Jialin Teng^a†, Yanping Chen^b†, Wenwen Zhang^b, Haotian Xu^a, Longfeng Ke^c, Huo Xu^d*, Jing Wang^a*
^a Key Laboratory of OptoElectronic Science and Technology for Medicine of Ministry of Education, Fujian Provincial Key Laboratory of Photonics Technology, Fujian Normal University, Fuzhou 350117, China

^b Department of Pathology, Clinical Oncology School of Fujian Medical University, Fujian Cancer Hospital, Fuzhou 350014, China

^c Department of Molecular Pathology, Clinical Oncology School of Fujian Medical University, Fujian Cancer Hospita, Fuzhou 350014, China

^d College of Materials and Chemical Engineering, Minjiang University, Fuzhou 350108, China

^† Equal contribution.
10.1021/acs.analchem.5c04448
Like two molecular locks guarding a treasure, the RCA–CRISPR cascade integrated with SERS establishes sequential checkpoints to unlock ultrasensitive and single-nucleotide-resolved detection of exosomal miRNAs. This layered strategy merges amplification, precision recognition, and optical readout, paving the way for reliable, next-generation cancer diagnostics.

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