Advanced Functional Materials
20 August 2018
Platelet–Leukocyte Hybrid Membrane‐Coated Immunomagnetic Beads for Highly Efficient and Highly Specific Isolation of Circulating Tumor Cells
Lang Rao1, Qian‐Fang Meng1, Qinqin Huang1, Zixiang Wang1, Guang‐Tao Yu2, Andrew Li3, Weijie Ma4, Nangang Zhang5, Shi‐Shang Guo1, Xing‐Zhong Zhao1, Kan Liu5,6,*, Yufeng Yuan4,*, Wei Liu1,4,5,*
1 Key Laboratory of Artificial Micro‐ and Nano‐Structures of Ministry of Education, School of Physics and Technology, Wuhan University, Wuhan, Hubei, China
2 Department of Oral Maxillofacial Head Neck Oncology, School and Hospital of Stomatology, Wuhan University, Wuhan, Hubei, China
3 Department of Biomedical Engineering, Johns Hopkins School of Medicine, Baltimore, MD, USA
4 Department of Hepatobiliary and Pancreatic Surgery, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, China
5 College of Electronic and Electrical Engineering, Wuhan Textile University, Wuhan, Hubei, China
6 School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, Sichuan, China
10.1002/adfm.201803531
In article number 1803531, Kan Liu, Yufeng Yuan, Wei Liu, and co-workers describe platelet–leukocyte hybrid membrane-coated immunomagnetic beads with enhanced cancer cell binding and reduced leukocyte interaction for highly efficient and highly specific isolation of circulating tumor cells from cancer patient blood samples. The novel hybrid membrane coating strategy presented in the work will open new possibilities for overcoming the limitations of current theranostic platforms.
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