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24 April 2025
Palladium Nanoparticles Degrade Advanced Glycation End Products via Valosin-Containing Protein Mediated Autophagy to Attenuate High-Glucose/High-Fat-Induced Intervertebral Disc Degeneration
Xiao Yang1,†, Xiankun Cao1,†, Xin Wang1,†, Jiadong Guo1, Yangzi Yang2, Liqiang Lu3, Pu Zhang1, Huan Yang1,4, Kewei Rong1, Tangjun Zhou1, Yongqiang Hao1, Jie Zhao1,*, Jingke Fu1,*, Kai Zhang1,*
1 Shanghai Key Laboratory of Orthopedic Implants, Department of Orthopedics, Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
2 Department of Orthopedic Surgery, Spine Center, Changzheng Hospital, Navy Medical University, Shanghai, China
3 Institute of Electrochemical Energy Storage, Helmholtz-Zentrum Berlin für Materialien und Energie, Berlin, Germany
4 The Second Clinical Medical College of Yunnan University of Traditional Chinese Medicine, Kunming, China
† Xiao Yang, Xiankun Cao, and XinWang contributed equally to this work.
10.1002/EXP.70036
Palladium nanoparticles (Pd NPs) mitigate High-Glucose/High-Fat (or advanced glycation end products, AGEs)-induced intervertebral disc degeneration (IVDD) by facilitating AGEs degradation. They enhance the ATPase activity of Valosin-containing protein (VCP) and promote autophagosome formation, leading to effective AGEs clearance.
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