Advanced Healthcare Materials
27 February 2023
Treatment with Mesenchymal Stem Cell-Derived Nanovesicle-Containing Gelatin Methacryloyl Hydrogels Alleviates Osteoarthritis by Modulating Chondrogenesis and Macrophage Polarization
Liying Pang1,2,3,†, Hong Jin2,†, Zhengmao Lu4,†, Fangyuan Xie5, Huaxing Shen3, Xinying Li2, Xinyi Zhang3, Xianghe Jiang6, Lili Wu1, Mengya Zhang1, Tinglin Zhang1, Yonghua Zhai6, Yuanyuan Zhang6, Huilin Guan7, Jiacan Su3,8,* Meng Li9,* and Jie Gao1,3,*
1 Changhai Clinical Research Unit, Shanghai Changhai Hospital, Naval Medical University, Shanghai, 200433 China
2 Department of Laboratory Medicine, Hongqi Hospital Affiliated to Mudanjiang Medical University, Mudanjiang, 157011 China
3 Institute of Translational Medicine, Shanghai University, Shanghai, 200444 China
4 Department of General Surgery, Shanghai Changhai Hospital, Naval Medical University, Shanghai, 200433 China
5 Department of Pharmacy, Shanghai Eastern Hepatobiliary Surgery Hospital, Naval Medical University, Shanghai, 200438 China
6 College of Life Science, Mudanjiang Medical University, Mudanjiang, 157011 China
7 Department of Scientific Research, Mudanjiang Medical University, Mudanjiang, 157011 China
8 Department of Orthopaedics Trauma, Shanghai Changhai Hospital, Naval Medical University, Shanghai, 200433 China
9 Department of Dermatology, Shanghai Ninth People's Hospital, Shanghai Jiaotong University, Shanghai, 200010 China
† L.P., H.J., and Z.L. contributed equally to this work.
10.1002/adhm.202300315
In article 2300315 by Jiacan Su, Meng Li, Jie Gao, and co-workers, GelMA-NVs, defined as gelatin methacryloyl hydrogels loaded with exosome-mimicking mesenchymal stem cell-derived nanovesicles (MSC-NVs), exhibit sustained release of MSC-NVs which could increase chondrocyte and human bone marrow MSC differentiation, proliferation, and migration and induce M2 macrophage polarization.
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