July 10 2025
Real-Time and Site-Specific Perturbation of Dynamic Subcellular Compartments Using Femtosecond Pulses
Seohee Ma1,2, Bin Dong1,2, Matthew G. Clark1, R. Michael Everly1, Shivam Mahapatra1,2, and Chi Zhang1,2,3,*
1 James Tarpo Jr. and Margaret Tarpo Department of Chemistry, Purdue University, 560 Oval Dr., West Lafayette, 47907 IN, USA
2 Purdue Institute for Cancer Research, Purdue University, 201 S. University St., West Lafayette, 47907 IN, USA
3 Purdue Institute of Inflammation, Immunology, and Infectious Disease, Purdue University, 207 S. Martin Jischke Dr., West Lafayette, 47907 IN, USA
10.1002/smsc.70045
It enabled single-organelle optical microsurgery and perturbation during imaging. Using femtosecond laser pulses with separately tunable peak and average power, fs-RPOC can generate reactive oxygen species and low-density plasma precisely only at targeted sites and simultaneously monitor their impacts on local and global cell functions.
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