您的浏览器目前处于缩放状态,页面可能会出现错位现象,建议100%大小显示。(快捷键:Ctrl+0)

当前位置:首页 > 图像设计 > 发表快报

ACS Appl. Bio Mater. - 广西师范大学赵书林教授、张亮亮副教授

发布时间: 2019-11-25 来源: ACS

Title: In Situ Ratiometric Fluorescence Imaging for Tracking Targeted Delivery and Release of Anticancer Drug in Living Tumor Cells

Abstract: In situ ratiometric fluorescence tracking the delivery and release of antitumor drugs remains a challenge for targeted treatment of cancer. Herein, we fabricated aptamer-functionalized biomass quantum dots (BQD-Apt) as the nanocarriers and probes for tracking the delivery and release of doxorubicin (DOX) in living cells. The fluorescence resonance energy transfer between BQDs and DOX in the formed BQD-Apt-DOX complex was inhibited after releasing DOX, achieving in situ ratiometric fluorescence imaging of delivery and release of DOX. Because of the good cancer-targeting ability of aptamer and biocompatibility of BQDs, BQD-Apt-DOX holds great potential for improving the efficiency of cancer treatment.

客服:400-070-3060